這次的病原還有另一個特點,就是它缺乏intimin蛋白。大腸桿菌用intimin蛋白來附著在腸道壁上,大部分的EHEC都具有intimin蛋白。不知該段原文是否是:Karch has found the strain to be eae-negative. The gene eae codes for the protein intimin, which the bacteria uses to attach to the intestinal wall. Most pathogenic EHEC serogroups are eae-positive. 倘若是,意思似乎是:該菌株的eae呈陰性反應。而eae基因為該種細菌用來附著腸壁的intimin蛋白質指定遺傳碼。多數致命之EHEC(由有類似血清反應的血清型組成的)血清組的菌株,eae呈陽性反應。請參考。
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Guinan, M. E., McGuckin-Guinan, M., & Sevareid, A. (1997). Who washes hands after using the bathroom?. American journal of infection control, 25(5), 424-425.
Ma, J. J. (2021). Blowing in the wind: Bacteria and fungi are spreading from public restroom hand dryers. Archives of Environmental & Occupational Health, 76(1), 52-60.
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聽起來好像大腸桿菌是好房客,又會禦敵又能生產有用的養份。不過,大腸桿菌也能在環境裡居住,而且會在撿到致病基因後重新回到舒適的腸道老窩。這時就不好玩了,這些大腸桿菌不再安份當個房客,會進一步攻入人體組織。其中在腸道裡危害嚴重的有:產毒性大腸桿菌(enterotoxigenic E. coli)、致病性大腸桿菌(enteropathogenic E. coli)、侵入性大腸桿菌(enteroinvasive E. coli)、出血性大腸桿菌(enterohemorrhagic E. coli)等等。不只腸道,泌尿道致病性大腸桿菌(Uropathogenic E. coli)還會從尿道進攻,在又酸又毒的尿液裡逆流而上,甚至攻進腎臟。這些病原,每年奪走好多人的性命,光是死在產毒性大腸桿菌手上的人就有數十萬。殺人兇手無誤。
這次的病原還有另一個特點,就是它缺乏intimin蛋白。大腸桿菌用intimin蛋白來附著在腸道壁上,大部分的EHEC都具有intimin蛋白。不知該段原文是否是:Karch has found the strain to be eae-negative. The gene eae codes for the protein intimin, which the bacteria uses to attach to the intestinal wall. Most pathogenic EHEC serogroups are eae-positive. 倘若是,意思似乎是:該菌株的eae呈陰性反應。而eae基因為該種細菌用來附著腸壁的intimin蛋白質指定遺傳碼。多數致命之EHEC(由有類似血清反應的血清型組成的)血清組的菌株,eae呈陽性反應。請參考。